Formulation and characterization of gallic acid and quercetin chitosan nanoparticles for sustained release in treating colorectal cancer
نویسندگان
چکیده
Cancer was ranked as the second leading cause of death, and colon cancer is recognized third most common worldwide with high morbidity mortality. Chemotherapeutic drugs act on normal cancerous cells similarly; therefore, they have various adverse side effects. The present study undertaken synergistic effect anticancer phytochemicals gallic acid isolated from amla fruit quercetin peels pomegranate incorporated into chitosan been used nanoplatform for targeted delivery to colorectal cancer. evaluated using cytotoxic assay such MTT in-vivo studies were performed DMH induced in Wistar rats. Identification biomolecules by different chromatographic spectroscopic techniques, 1H NMR, GC-MS, LC-MS, HPTLC. Characterization (CS) nanoparticles carried out X-ray diffraction (XRD) Differential scanning calorimetry (DSC), Scanning Electron Microscope (SEM), entrapment efficiency In vitro drug release confirmed successful encapsulation nanoparticles. A significant change aberrant crypt foci (ACF) CS compared polyherbal extract observed, a decrease colonic glutathione, catalase superoxide dismutase levels values differed significantly (P < 0.005). techniques. XRD, DSC, SEM In-vitro levels.
منابع مشابه
formulation and characterization of ionotropic cross-linked chitosan microspheres for controlled release of ascorbic acid
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ژورنال
عنوان ژورنال: Journal of Drug Delivery Science and Technology
سال: 2021
ISSN: ['1773-2247', '2588-8943']
DOI: https://doi.org/10.1016/j.jddst.2021.102523